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Pharma franchise business in Anti-allergy & anti-cold products

by new_pharma new_pharma No Comments

The need for medicines is increasing in this modern life. But there are certain medicines which were needed in the past and are in high demand now also. They include the anti-allergy and anti-cold medicines. Allergies and common cold are among the most common health problems faced by almost all people especially children.

Due to this reason many people like to invest in the pharma franchise business of these medicines. Before discussing the benefits of investing in these products, let’s discuss anti-cold and anti-allergy medicines.

Anti-cold medicines:

Anti-cold tablet is a combination medication, which is used for the treatment of common cold symptoms. It alleviates the symptoms of allergy like sneezing, runny nose, congestion, stuffy nose and watery eyes.

It assists to loosen the thick mucus that makes it easy to cough out. This ultimately makes the movement of air in and out easy. It contracts the blood vessels and offers fast relief, which lasts for many hours.

Anti-cold tablets generally begin to act within a few minutes and their effects last for many hours.

It is administered with or without food in a dose recommended by the doctor. The dose of this medicine will depend on the condition of the person and how they react to the medication.

Anti-allergy medicines

Allergies are an overreaction by the immune system of the body to a foreign substance, which is not considered harmful to your body. Substances, which cause allergies, are called allergens.

Usually, there is no cure for allergies, but certain medicines can assist to alleviate and treat its symptoms such as runny nose and congestion. These anti-allergy drugs include antihistamines, corticosteroids, decongestants, combination drugs and others.

Benefits of investing in pharma franchise business of anti-allergy and anti-cold medications

There are many reasons for the rising demand of the anti-allergy and anti-cold medications:

• As the pollution is increasing every day, lifestyle is changing and the exposure to sudden weather changes in this populated environment is the cause of increasing occurrence of allergies and cold. Due to which the demand for anti-allergy and anti-cold medicines is increasing.

• The increasing awareness for the treatment of allergies is raising the need for these medicines.

• The franchise business for these medicines can be started with a low investment. You do not require huge amounts to spend.

• These medications are kept by the people to treat sudden allergy attacks. They are available with over-the-counter and prescription-based mode. Their demand is very high.

• These medicines will always be in demand. The allergies and common cold are among the most frequent health issues faced by all people.

Therefore, many people are investing in the pharma franchise business of this drug range.

If you are interested in investing in the pharma franchise business of these medicines, then let us introduce you to the best pharma franchise company.

Best pharma franchise company for anti-allergy and anti-cold products in India

Pharma Franchise World is a renowned PCD pharma company in india. Due to our quality services, we are now working to expand our business all over India. We have a team of skilled and qualified members . We examine and go through the quality of all our products.

Our Company is supported by the advanced technologies that assist us to produce the products of the latest standards .

All these reasons are responsible for having many clients all over the world.

Features of Pharma Franchise World:

• All production of pharma products is done in GMP certified units.
• We offer ASM Bags, Visual Aids, LBL, MR Bags Reminder Cards, as part of marketing strategy.
• Our company keeps all our business associates and franchise informed about the product.
• We offer incentives for meeting annual targets.
• We offer a Monthly Promotional Scheme.
• We offer Order Execution Turnaround within 24 hours.
• We have a complete choice of products like Tablet, Dry Liquid, Capsule, Injectable, Liquid, Antibiotics.

Quality has been one of the primary goals. Because of our quality services we are a trusted brand name in our sector.

We are an ISO 9001:2008 & GMP Certified Ethical PCD Company. We have extended our services and resources to all regions of India by providing outstanding PCD pharma franchise opportunities.

We provide:

• Timely Services
• Regular Supplies
• Fast and hassle free business
• Transparent Dealings
• No Supplies without Confirmed Orders
• Attractive Packaging
• Most Competitive Rates
• Assured Monopoly
• Honest Transactions
• Promotional Inputs

Joining the pharma franchise world will help to progress in the field of pharma franchise business. You can easily invest in the anti-allergy and anti-cold products of this company. It will not require huge investment or any harassment.

Pharma Franchise Opportunity in Orthocare Products

by new_pharma new_pharma No Comments

In modern life the prevalence of diseases is increasing. The major prevalent disorders include obesity, hypertension, arthritis and diabetes mellitus.

The fast economic development and increasing westernization of lifestyle has contributed a lot in increasing these health conditions. Due to which the demand for medicines has also increased.

To meet the increasing demand the pharma franchise business has achieved an extreme growth.

In this article, we will discuss the Pharma franchise opportunity in India for Orthocare products.

Before discussing it, let’s explore:

What are Orthopaedics and Ortho care products?

Orthopaedics are the medical experts that focus on disorders and injuries of the musculoskeletal system of the body. This system includes bones, muscles, nerves, joints, ligaments and tendons. It is responsible for allowing us to move, work, and be active.

Common orthopaedic conditions include:

  1. Acute injuries: Includes bone fractures and dislocated joints.
  2. Arthritis: It is joint inflammation that causes pain, joint damage and loss of joint function. It is of more than 100 different forms like gout, osteoarthritis, psoriatic arthritis and rheumatoid arthritis.
  3. Bursitis: It is the irritation and inflammation of a bursa. Bursae are sacs filled with fluid inside the joints, which cushion the ligaments, muscles and tendons.
  4. Muscle atrophy: It is the loss of muscle tissue that causes the difficulty in movement and weakness. It is developed due to lack of use in situations like being bedridden.
  5. Musculoskeletal cancer: It is the malignancy of any of the tissues of the musculoskeletal system.
  6. Orthopedic autoimmune diseases: They develop when the immune system of the body mistakenly begins to attack its own healthy cells. Rheumatoid arthritis, lupus, psoriatic arthritis and scleroderma are some of the autoimmune disorders, which can affect the musculoskeletal system.
  7. Osteomyelitis: It is an infection in the bone.
  8. Osteoporosis: It occurs when there is loss of bone density that makes the bones weak and brittle. Due to this disease the risk of fractures increases.
  9. Tendinitis: It is the irritation and inflammation of a tendon. It develops due to injury from repetitive motions.
  10. Tenosynovitis: It is the inflammation of a tendon sheath.

Orthocare products are used for preventing and treating the deformities and injuries of the musculoskeletal system in our body. Various pharmaceutical companies manufacture these products as they are in high demand.

Therefore, the pharma franchise opportunity in Orthocare products is also very high.
If you are looking for pharma franchise business opportunities then you can choose ortho products. This is due to certain significant reasons.

But before discussing the benefits of investing in Pharma franchises of Orthocare products, let’s discuss the causes of increasing demand of orthocare products:

  1. Ortho care products are in high demand as there are huge numbers of people suffering from orthopedic conditions. The elevating incidences of osteoporosis, sports injuries, obesity and osteoarthritis are responsible for these elevated demands of ortho products.
  2. Surgeries associated with the musculoskeletal system are increasing with time. Also, the medicines needed for surgical and non-surgical Orthopaedics is increasing. The major cause behind this is declining mortality and poor lifestyle.

Benefits of investing in Pharma franchise of Orthocare products

  1. Pharma franchise opportunity in Orthocare products is great if you want to expand your business. As the demand for ortho products is high therefore, it offers good profit margin.
  2. The investment for the PCD ortho franchise is very low.
  3. The risk of failure or loss is very low as ortho products and medicines are used in routine.
  4. You can start your business independently and set your own targets according to your wishes and will. By investing in this pharma franchise business you get a chance to get into independent business. On the other side, patients also get medications at their place without getting any difficulty.
  5. With the increasing demand of ortho products, their distribution is also needed on a large level. This franchise is beneficial for both patients and newcomers.
  6. There is a rising number of ortho patients in clinics and hospitals. They need ortho products for a long time for therapies and treatments of trauma, joint reconstruction, repair, arthroscopy and knee and joint surgeries.
  7. People suffering with orthopaedic conditions require quality medications and other related products regularly. To fulfill this high demand franchise business is offered by the companies. Orthopedic Products Franchise works best to fulfill the increasing needs of these products.

Therefore, you can understand that the ortho sector will surely grow in the coming years. However, choosing the right pharma franchise company is also a critical step in the field of pharma franchise business.

Best pharma franchise company for ortho products in India

Pharma Franchise World is a prominent PCD pharma company in India. Due to our quality pharma products we are working to expand our business all over India.

We have a team of well skilled and trained members. We explore and go through the quality of all our products. Our company is carried by the advanced technologies that assist us to obtain the products based on the most modern standards.

All our production of products is carried out in GMP certified units. Delivering quality products is the primary goal of our organization. This makes us one of the trusted and well-accepted brands among Indian PCD pharma franchise companies. Now we have extended our services to almost every part of the country by providing first-class PCD pharma franchise opportunities.

Our chief motto is to spread the company’s name in the world by providing more franchise opportunities to newcomers. Our company is partnered with many reputed companies and brands. Our team will assure that you receive positive outcomes in terms of sales and long-term relationships with our company. Due to all these reasons we have clients globally.

Our company offers:

  1. Services on time and regular supplies.
  2. Fast and stress free business.
  3. Long-term clear business.
  4. No products without order confirmation.
  5. Attractive Packaging.
  6. Most reasonable prices along with guaranteed monopoly.
  7. Honest Transactions.
  8. Promotional support in the form of Reminder Cards, Visual Aids, LBL, MR Bags ASM Bags.
  9. Incentives for meeting yearly targets.
  10. Wide range of products.

Therefore, you can easily start pharma franchise business in orthocare products with the pharma franchise world. It will be a profitable and long-term franchise business opportunity with low investment.

Anti-diabetic products for PCD Pharma Franchise

by new_pharma new_pharma No Comments

Today, around half a billion people around the world are living with diabetes, and these figures expected to rise by 25% in 2030. Out of all type of diabetes, about 90% of diabetic patients are known to suffered from type 2 diabetes mellitus (T2DM).

Asia is turned out to be a major region with promptly emerging T2DM cases, with China and India as the top two epicenters. This has deeply affected the whole global pharmaceutical market and pcd pharma franchise.

Let’s take a brief look on diabetes status in India and associated opportunities in the anti-diabetic pharmaceutical market:

  1. What is diabetes?
  2. Status of diabetes in India
  3. Benefit to start a business in the diabetic drug market
  4. Why choose the pharma franchise world?
  5. Pharma franchise world’ anti-diabetic range

What is diabetes mellitus?

Diabetes mellitus is a condition of raised blood sugar levels that occur due to the cluster of metabolic disorders.

According to WHO, diabetes occurs when the pancreas doesn’t produce proper insulin (a hormone that regulates blood sugar levels), or when the body is unable to utilize insulin the body produces.

Type 1 diabetes is marked by insufficiency or absence of insulin, and Type 2 diabetes is marked by insufficient use of insulin. Over time, uncontrolled diabetes can lead to various health implications associated with eyes, kidneys, blood vessels, heart, and nerves.

Status of diabetes in India

Diabetes is one of the major health concerns in India. People in India get diabetes at an average 10 years sooner than Western counterparts. There are about 61.3 million people from age 20 to 79 found to have diabetes and this number is foreseen to increased to 101.2 million by 2030.
It influences both rural and urban population, however, the impact on people living in urban areas are higher. The most alarming part is the shift in the age of onset of this disease towards a younger age.

Benefit to start a business in the diabetic drug market

This disturbing situation of diabetes in the Indian population has profoundly enhanced the demand for anti-diabetic medicines and associated healthcare products in India. The anti-diabetic section is the second fastest-growing therapeutic segment after oncology.

Indian pharmaceutical industry is witnessing 15% growth in insulin segment and 25% growth in overall anti-diabetic medications segment.

Furthermore, the growing investments in the development of anti-diabetic products and favorable reimbursement policies enhance the growth diabetic drug market.

This creates many lucrative opportunities in this business. Therefore, it is not wrong to say that start a business in the diabetic drug market is a productive thought.

To set up a new start-up in the anti-diabetic market, pcd pharma franchise can help you to get better growth opportunities and hold on consumers. The pharma franchise world, a renowned pcd pharma franchise company provides the best opportunity for those who want to start their own business in pharmaceuticals.

Why choose the pharma franchise world?

Pharma franchise world is an eminent name in the world of the pharmaceutical franchise business. The company involved marketing of more than GMP certified 200 high-quality pharmaceutical products. Based on quality services, well-qualified team members, modern and advanced technologies, the company is on wheels of expanding its business all over India.

For the anti-diabetic pharma franchise, we invite all the leading and fresh professionals, who want to try their hands in this sector. We are very competent to provide the best assistance to flourish and set-up your business.

# We offer the best monopoly rights with the most competitive rates.
# We provide a high-quality guarantee with a range of anti-diabetic products.
# Our products are highly effective and meet all the guidelines.
# We believe in transparent and ethical business.
# The timely and well-packed delivery of products is our first priority.
# We provide 100% marketing support, including prescription pads, order books, visiting cards, visual aids, brochures, writing pads, and product glossary.
# We keep updating all our franchise partners regarding products.
# We provide an Order Execution Turnaround within 24 hours.
# We provide Incentives for meeting annual targets.

With all these services and support, the Pharma franchise world has trustworthy clients all over the world. We are pleased to offer a healthy business habitat for our clients and open doors for new professionals to set-up their business in the Indian pharmaceutical market. To know more about pcd pharma franchise, click here.

Pharma franchise world’ anti-diabetic range

You can commence your own venture. Pharma franchise world offers various anti-diabetic medications to tackle the problems like high blood sugar levels, hepatic gluconeogenesis and reduced intestinal glucose absorption. These anti-diabetic products are formulated with world-class advanced technology and with unabridged quality control. We offer:

  1. Glimepiride tablets
  2. Glimepiride and metformin hydrochloride tablets
  3. Methylcobalamin, l methylfolate calcium & pyridoxal 5 phosphate capsules

So, start your business journey in the world of pharma franchise business with these best quality anti-diabetic products and give your business an excellent perk and success.

Most-in-demand pharmaceutical categories for pharma franchise pcd

by new_pharma new_pharma No Comments

Franchising is getting countless exploration in low-, middle-, as well as high-income countries as an organizational template to surmount certain challenges in the healthcare sector. Pharma franchise pcd is a contractual agreement amongst the franchiser and the franchisee, by which the franchisee has the privilege to market products or services under the franchiser’s company brand.

The major segment which plays an essential part in getting success from the pharma franchise business is the correct choice of drugs for the market. Pharma franchise companies deal with multiple ranges of pharma products, however, the market and CAGR (compound annual growth rate) of every drug segment is different.

If you are unable to find the right segment you want to start a business with, then you’re at the ideal place.

The following given information and statistics can help you to get a clear picture.

  • Dermatological Products
  • Hepatology range
  • Nutraceuticals
  • Cardiac range
  • Diabetic range
  • Orthopedic range
  • Gastroenterology range
  • Common cold drugs

Let’s explore all the pharmaceutical products ranges individually:

#Dermatological Products

Skincare is one of the most prominent and demanded industry in India. The dermatological products are the best deal for people who want to join or start the pharma franchise enterprise because the pharma franchise market of dermatological products is rising exponentially. The people are taking interest in keeping their skin spotless, charming, and healthy.

The global market for these products is increasing at 8% CAGR. In the context of Indian dermatological drug market is cultivating twice of the European market. Up to 2022, it is estimated that the demand for these products can increase by up to $33.7 billion.

This market offers a range of products in the context to deal with skin, hair, and nail problems. It can be cleansing agents, moisturizing agents, emollients, astringents, ointments, anti-fungal, and many more. Therefore, starting a business with the derma franchise can be a good venture.

#Hepatology range

The most eminent hepatologists of India have a belief that the future of the hepatology health industry is promising in this country. The gigantic advances in the handling of liver-associated problems.

Moreover, the global liver disease market is forecasted to accumulate around $19,536 million by 2022. The Indian market of this sector is also expected to experience a great surge in the future. So, if you have a good market around, choosing a hepatology range for franchise can give you profit.

#Nutraceuticals

The word is originated from two different terms; “nutrition” & “pharmaceuticals”. In today’s date, where everyone’s priority is to keep their health up-to-mark, the investment in nutraceuticals is surely a business of benefit. Because nutraceuticals are the major market that enriches people with nutrients that they are deprived of. As compared to past years, the demand for these supplements found to be rise by 20 percent.

The population living in urban areas of India has a deeper insight of 22.5% of nutraceutical products. Therefore, by selecting an adequate region and market, the chances of getting higher benefits from this investment are extremely high.

#Cardiac range

The demand for cardiovascular drug market in India is rising at a striking rate of 5.8%. In the growth of the Indian pharmaceutical industry, these products play a major role. The CAGR of this market also estimated to rise by 1.2% through 2020.

Therefore, starting a franchise career by investing in this pharmaceutical sector surely gives your business a great profit.

#Diabetic range

It is expected that the CAGR of diabetic medications between the years of 2016-2023 get an exposure of 6.5 percent.

India is counting among the most diabetes-affected countries. That is the reason, why the diabetic drug market is flourishing in India day by day. Therefore, as the cardiac drug market, the investment in the diabetic franchise market is also a business of profit.

#Orthocare range

This is one of the other medicine sectors, which can give your business a good run. There are about 39% and 61% of patients suffered from ortho-related problems in urban and rural areas, respectively. Many orthopedic patients went through treatments and surgeries every year. So, starting a franchise business with this can also a good deal.

#Gastroenterology range

Gastroenterology is a branch of internal medicine that deals with the problems of the GI tract, that is, the esophagus, small & large intestine, stomach, liver, and pancreas. The market of these products is also associated with great benefits due to rising awareness among people regarding their health, especially metabolic and digestive health.

The CAGR of the GI sector is likely to increase by 4.7 percent. The market is growing at its fastest pace and investing in this surely profit your business.

#Common cold drugs

This market has its own importance. With changing seasons and weathers, persons met with the problems of cold, flu, or cough. These medicines provide relief to the people from these common health problems. This is also can be a profitable deal.

These are the most-in-demand pharmaceutical product categories that you can think of and start with as all these categories have their own markets and provide profits accordingly. Further, to start with franchise business trustworthy, pharma franchise world is the best place to begin with.

Why pharma franchise world?

The pharma franchise world is one of the top leading pharma franchise company of India, which deals with more than 200 high-quality products of different range and categories. The company provides all the platforms to raise business and led your investments on the right path. Explore more about the pharma franchise and for any inquiries freely contact us.

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How pharma franchise business can help in the COVID-19 crisis?

by new_pharma new_pharma No Comments

The Indian pharma industry contributes 60% in the vaccine formation worldwide and considered as the world’s third-biggest drug manufacturer by the volume. However, the COVID-19 crisis has jolted the Indian pharmaceutical sector up including pharma franchise business to a great extent. Starting from Wuhan, novel coronavirus is become omnipresent and lead incurred destruction.

Let’s explore what impact the COVID exerts on society and how the pharmaceutical business get affected from it:

-COVID-19 Crisis
-Impact of COVID-19 on the pharma sector
-What is the pharma franchise business?
-How pharma franchise company is helping in the COVID-19 crisis

COVID-19 crisis

Today, we are juggling with the once in a century crisis. We are facing the biggest global health crisis of our era. The coronavirus pandemic is spreading like a wave and crash those who are least able to cope. Governments all around the world are rushing to slow down this speed by treating patients, limiting international and national travel, seizing all large gatherings like schools, colleges, malls, sport events and quarantining citizens.

Although, COVID-19 crisis is much more than a health crisis. It also involves economical, social and political crisis. One of major impact that this crisis has put is the pharmaceutical sector.

Impact of COVID-19 on the pharma sector

The Indian pharmaceutical industry is also gone through its major crisis in this pandemic. The very first attack of COVID-19 crisis is on medicines prize. The costs of many medications like penicillin, paracetamol, supplements and many more are raise twofold or triple to its previous cost.

This all happens due to the expanded manufacturing plant termination in China. Indian pharmaceutical sector is majorly depends upon china for APIs (active pharmaceutical ingredients), which are key step to formulate medicines. Due to the impact of COVID-19, supply chains and product exportation is disrupted due to manpower shortages, quarantine polices, hinder transportation systems and restricting access on goods internationally.

However, this dependency of Indian pharmaceutical companies upon China for APIs led the Indian government to establish a task force to assess internal API sector. Recently, government of India has also undertaken an initiative step towards it.

Government proposed an incentive package of 13.76 billion Indian Rupees for accelerating the internal production of important pharmaceutical materials like APIs, medical devices and drug intermediates. Also, India is leading in manufacturing PPE kits. Government is doing all initiatives to make Indian pharmaceutical sector as a self-sustained unit in this crisis. In this, pharma franchise business also play an essential role.

What is pharma franchise business?

Pharma franchise involves an official permission or approval provided by the pharma companies to an individual, groups or distributors to spread their business to different parts around the country or outside the country. Therefore, a pharma franchise company gives a great platform for marketing and sales of pharmaceutical goods in concerned areas. It is also known as pharma franchise PCD. PCD refers to Propaganda-Cum-Distribution i.e. PCD pharma franchise company that provides brand name, products and all associated support to their franchise partner.

In this pandemic crisis, the pharma franchise PCD shows a significant role.

How pharma franchise company is helping in the COVID-19 crisis?

The pharma franchise took a very initiative step which definitely helps to reduce this health and economic crisis.

1) Timely distribution of medicines
Medicines be always an essential part of many people. Today in the scenario of lockdown, people who are encountering with certain health problems such as cardiovascular diseases, diabetes, and thyroid issues etc. need a proper medication regularly. To cope up these needs, dealers must have the sufficient stock of such essential medications.

Here, a pharma franchise company plays a very essential role. With the help of professional relationships and specific permits, these companies helps to distribute all the essential medications to their distributors with same pace and enthusiasm.

2) Creates new boundaries
These days, there are some areas, where health sector is not in good condition. People over their face problems in getting their essential medicines. Pharma franchise also tries to create new boundaries and making new connections to deliver its products to all possible corners of the nation.

3) Delivers healthcare essentials
These pharma franchise companies are modulating and prepare themselves for a new change in a very short time. A time when the spread of coronavirus has swiped all the hand wash and sanitizers from the market hands-on hands, PCD pharma franchise companies had presented new range of these health essentials and help to cover their shortage in the markets by distributing at all corners of the India.

4) Builds up economy
This is one of the major industries along with food and essentials, which is open and doing work effortlessly to fulfill the needs of consumers. The regular pace of sales in the pharma industry may help to cope with the down economy of the nation.

5) Fast, reliable, and certified service
In this world of crisis, a pharma franchise company makes all efforts to provide all the facilities on time with full safety measures. These companies all taking updates via telephonic or internet medium to ensure all the required demands.

All these efforts of a pharma franchise company help can help the government to overcome the COVID-19 crisis.

There are many leading pharma franchise companies that are active in this time of need and the pharma franchise world is one of those, which is working day and night to fulfill the demands of distributors and consumers. To know more, you can click here.

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10 Best Pharma Franchise Companies to Look Forward in 2021

by new_pharma new_pharma No Comments

The pharmaceutical industry in India is ever-evolving. The increase in economic growth has led to a massive demand for quality healthcare products and medicines in the country. With India predicted to be the 6th largest market for pharmaceuticals globally by 2021 as per the latest report, the number of business opportunities to the pharma professionals is increasing, which includes PCD Pharma Franchise. The pharma professionals want to associate with the top Pharma Franchise companies for a good start.

Investment in the right pharmaceutical company can cater your business to ensure better and faster growth. With more than 50, 000 registered pharma companies in India, investing in the best Pharma Franchise company is a strenuous task.

  1. Pharma Franchise World
  2. Auzalus Lifesciences
  3. Solitaire Pharmacia
  4. Genesis Biotech
  5. Dr Best Pharmaceuticals Ltd.
  6. Medok Lifesciences Pvt. Ltd.
  7. Innovexia Life Sciences
  8. Healthkind Labs Pvt. Ltd.
  9. Amzor Healthcare
  10. Ventus Pharma

Need of Pharma Franchise Company in India:

The PCD Pharma Franchise is a leading business these days, rendering it an exceptional spot of investment that offers both profits along growth to a businessman. There is a growing demand for a good pharmaceutical company that can help to grow your business better and efficiently day by day. Accordingly, the basic need of Pharma Franchise company is to provide a businessman with a platform for their development by their incredible work in the field of the healthcare sector.

Basics requirements to look for companies best for Pharma Franchise business are as follow:

  1. WHO, ISO 9001:2015 certified company
  2. More than 200 Products
  3. Reach Experience
  4. Spacious warehouses
  5. Offers a wide range of products approved by DCGI
  6. GMP Certified & GLP Manufacturing Collaboration
  7. Up-to-date Manufacturing Association
  8. Offers support regarding the promotional Inputs, for example, LBLs, Visual Aids, Reminder cards, Visiting card, Order books, MR bags, etc.

Keeping in mind these features, we present a list of the top 10 well-known and trustworthy Pharma Franchise companies in India which are best for PCD Franchise business for your convenience:

1. Pharma Franchise World:

Pharma Franchise World, one of the best Pharma Franchise companies in Chandigarh, India has a wide range of almost 200 + high-quality pharma products. This certified company is devoted to providing high-quality medical products with novel technologies and exclusive marketing solutions. It is one of the fast-growing firms in the pharmaceutical sector for many years.

Pharma franchise world offers support with all marketing strategies and promotional backup, helping you to increase the sale. The qualified and experienced Product Management Team (PMT) keeps the doctors up to date with an up-to-date national/international standard. They thoroughly analyse and go through the quality and purity of all the products.

The product range targets to improve the overall health with effective results, varying from Anti-inflammatory, Analgesic, Antispasmodic, Anti-allergy/Anti-cold, Neurotropic, Anti-diabetic, Anti-acne, Hair supplements, Gastroenterology, Libido/ Vitality/Fertility, Orthocare, Protein supplement, Sunscreen, Medicated soaps, to name a few. These are available in diverse formulations, as tablets, syrups, capsules, injectables, topicals and more. This company is well supported by modern and advanced technologies.

With over 20 years of experience in providing expert financial advice, its financial specialists guarantee you get the optimum results. There is a young, enthusiastic team of advisors who are always available to help.

Pharma Franchise World Offers :

Pcd Pharma Franchise in Mumbai
Pharma Franchise Company in Ahmedabad
Pcd Pharma Franchise in Bangalore
Pcd Pharma Franchise in Gujrat
Pcd Pharma Franchise in Chandigarh
Pcd Pharma Franchise in Delhi
Pcd Pharma Franchise in Maharashtra
Pcd Pharma Franchise in Bihar
Pcd Pharma Franchise in Himachal Pradesh
Pcd Pharma Franchise in Kerala
Pcd Pharma Franchise in Punjab
Pharma Franchise Company in Uttarakhand
Franchise pharma company baddi
Pcd Pharma Franchise in Karnataka
Derma products franchise company in India
Pcd Pharma Franchise in Chennai
Pcd Pharma Franchise in Chhattisgarh
Pcd Pharma Franchise in Tamil Nadu
Pharma Franchise Company in Mumbai
Derma Franchise Company in Ahmedabad

2. Auzalus Life Sciences:

Auzalus Life Sciences aims to cater to the global therapeutic needs with innovative solutions and provide quality assured and most effective medicines at the most affordable prices. We seek to improve the quality and efficiency of products along with the hope of introducing next-generation products with time.

It is run by a core of an experienced, competent team of professionals who bring together knowledge from many arrays of fields in the Pharma Industry. Auzalus Life Sciences seeks to attain a leadership position in the key markets with the distribution of an innovative and quality assured range of products.

The Therapeutic segments covered by Auzalus Life sciences are :
Orthopaedic Range
Gynaecology Range
Pediatric Range
Dermatology Range
Nutraceutical & Calcium Supplements Range
Respiratory & Anti-allergic Range
Gastrointestinal Range
Hepatology Range
Neurotropic Range

3. Solitare Pharmacia:

Solitaire Pharmacia is one of the fastest-growing Pharma Company in India, based in Chandigarh. It has an established history of reliability and performance with an extensive range of medicines and drugs. These include Contraceptive Pills, Hormonal Tablets, Dry Powder Injection, Psychotropic Tablets, Diabetic Tablets, Cardiac Tablets, Anti-cancer Medicine, Antibiotic Tablets, Anti-malarial Tablets, Anti-ulcer Tablets, Muscle Relaxant, Protein Powder, Women & Child Care Drugs, Ortho Care Drugs, Day to Daycare Drugs, Eye/ Ear & Nasal Drops Lifesaving injectables, etc. which are formulated with purity and are safe to use. With the manufacturing and supply of top quality medicine along with a wide range of compositions and competitive pricing, Solitaire is the most effective partner to supply your medical necessities.

4. Genesis Biotech:

This is ISO 9001:2008 certified company that have a widely accepted ethical PCD pharma franchise for derma range approach all over the nation. This Pharma Franchise company in India offers monopoly pharma franchise with a range of health & wellness products free from impurities and packed with nutrients.

This company is aimed at providing marketing premium health and wellness products at affordable prices, in agreement with the International quality standards. This product range is certified by the highest organisation like FSSAI, DCGI and FDA.

Various pharmaceutical products have marketed that address the therapeutic areas.

5. Dr Best Pharmaceuticals Pvt. Ltd.

With a vision to become a leading pharmaceutical company in the global market through innovative ideas, DR BEST Pharmaceuticals Pvt. Ltd. is an emerging name in the area of providing the finest quality healthcare products concerning a host of therapeutic segments such as Antibiotics, Anti-Diabetic Drugs, Lipid-lowering Agents, Cardiovascular, Gastrointestinal, OTC, Analgesics, Vitamins and many more Products. The manufactured medicines are WHO GMP/ cGMP compliant supported by a group of enthusiastic professionals belonging to R & D, QC, QA.

6. Medok Lifesciences Pvt. Ltd.

With a wide range of products of General, Gynae, Ortho, Pediatrics, Beta-lactum/Non-Beta lactum, Gastro and Food supplements, Medok Life Sciences established in 2010 is one of the renowned and well-established pcd pharma franchise companies in Chandigarh. Medok Life Sciences has expertise in pharmaceutical contract manufacturing owing to its years of experience in pharma manufacturing. It understands the market needs very well and accordingly works to the need and demand of the market without breaching its pledge of quality.

7. Innovexia Life Sciences

Established in the year 2011, Innovexia Life Sciences is involved in manufacturer, supplier, trader and distributor quality assured the range of Pharmaceutical Medicines. It markets a wide range of medicines – some of them are lifesavers, whereas others improve the quality of life for many people. The diverse range of formulations- tablets, Capsules, Ointments, Injectables, Syrups, Protein Powder and other Pharma Products are manufactured from high-grade chemicals, protein, vitamin, minerals and other material in the precise composition. Innovexia Life Sciences have a strong capacity and market knowledge required for pharma startups seeking companies offering Pharma pcd in Chandigarh.

8. Healthkind Labs Pvt. Ltd.

Being an ISO 9001:2008 certified company, Healthkind Labs Pvt. Ltd. is engaged in manufacturer, supplier, trader and distributor quality guaranteed range of Pharmaceutical Medicines. Well-found with a world-class chemical testing facility, worked by reputed chemists, Healthkind Labs strive to provide only pure and quality drugs. This WHO & GMP Certified pharmaceutical company offers a monopoly based PCD Pharma Franchise in Chandigarh and throughout India.

9. Amzor Healthcare

Amzor Healthcare is committed to ailing mankind and cares for life. Amzor Healthcare is known for delivering what they commit to their stakeholders, business partners, customers, patients, employees, investors and everyone who soever is connected with the company. As it is an ISO 9001:2008 certified company, all the norms and regulations set by authorities are followed. Amzor Healthcare has an excellent team of experts and highly professional and committed pharma experts, which makes it a trustworthy name among its customers and associates.

10. Ventus Pharma

With a vast product line contains pharmaceutical tablets, capsules, nasal drops, injectables, soft gels capsules, protein powder, mouth wash and gel, and ayurvedic herbal products and many more, Ventus Pharma is on the path to gain the top spot in the Indian pharmaceutical industry.
Ventus Pharma, the best pharma franchise company also called a prominent ayurvedic pharma PCD company. With almost 100+ DCGI certified pharmaceutical products and AYUSH certified ayurvedic products Franchise that covers numerous therapeutic segments and accomplishes the most stringent quality guidelines outlined by the industry.

All these companies are supported with world-class infrastructures and the latest technologies along with being engaged in manufacturing huge quantities of pharmaceuticals of all kinds. You can consider these companies if you are sincerely looking for worthy growth prospects.

Online Medicine Purchase in India – Pros and Cons

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Given the busy lifestyle, Internet or online shopping is a favorable choice for many! It has become a convenient option for shopping as we get everything delivered at your door-step only with a single click. Along with other products, people are also going for online medicine shopping in India

Pros and Cons of Online Medicine Shopping in India!
As per a research by foreign brokerage, CLSA, “E-pharmacies are expected to grow seven times to $3.7 billion by CY22 as they focus to grab a large section of the highly fragmented Indian market”

 

What is online pharmacy?
Online pharmacy is the platform which enables direct selling of medicines, daily care products from the internet stores to consumers. These are the 24-hour operating online stores where a medicine is sold via e-mail or placing online order at any time.
E-Pharmacy cuts down the long chain of distributors and provides medicine to the end-user at a lesser price. One can receive a lot of para-pharmacy or over-the-counter (OTC) drugs at home without moving from the sofa as they do not require a prescription.

How to purchase medicines by online pharmacies?
First step is that you should always buy medicines prescribed by the physician, self medication can be even more fatal. After you get prescribed any particular medicine, make sure about the availability of the medicine with the online pharmacy, go through the catalogue.
Familiarize yourself with their collection, read the annotation, dosage, contra-indications, compare the drug with its correspondents, etc. To have a clear picture, follow the steps as:

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People also ask, is buying medicines online beneficial?
Undoubtedly, the cheaper costs and comfort makes online medicine shopping even more favorable! Some other advantages are described below:

Benefits of buying medicines online:

Benefits of buying medicines online

  • Maintains the anonymity of the user and offers discrete services:

    Sometimes physically buying medicines can be embarrassing for some and discussing some treatment of intimate problems with the pharmacist is not always convenient. But, this awkwardness can be saved by ordering medicines online and avoiding such discomfort without prying eyes!
  • Medicines at cheaper and discounted prices:Medicines at cheaper and discounted prices
    Medicines are costly, but now you can avail the medicines at cut-rate prices. Many websites offer great discounts, seasonal sales and even cashback offer all year-round. Due to the ventures like pharma franchise and generic medicine sales, it is even more convenient to buy medicines. The cost-cutting factor is probably due to the fact that there is no money spent on renting premises, and maintaining a huge staff, including sellers, and thus unnecessary costs can be dodged.
  • Easily accessible and convenient:Easily accessible and convenient
    The product information is fairly more understandable and accessible online than in traditional pharmacies. There are no long queues to buy medicine but rather it is a hassle-free process.
    An online pharmacy is the best substitute since these pharmacies deliver products straight to your doorstep 24*7. There are online pharmacies where on-call doctors are available to diagnose your medical history and help in checking your medicine order even if you don’t have a prescription.
  • Offers an extensive range of medicines:online shopRanging from cosmetics to hygiene products, you can also pick from a wide choice of drugs i.e. both brand and generic names. Moreover, before purchasing the product from the website, you can take the time you need to study all the related details, usage instructions, description, product composition and side effects, without any haste and fuss.
  • Easier to compare prices while toggling between different online pharmacies:Easier to compare prices while toggling between different online pharmaciesYou can easily compare the prices for different medicines just by switching tabs to visit site to site. To have an idea of the best buy, average price, it is always a good practice to check 2-3 sites for the prices.
  • Pick from different payment options:Pick from different payment optionsSeveral payment options are available, which allows the consumer to pay for their drugs easily, for example, cash on delivery (COD), credit or debit card, or other online payment modes. The traditional brick and mortar pharmacies don’t have such suitable payment options.While there are many advantages of buying medicines online, the disadvantages for the same cannot be ignored. Rather than providing the precise treatment drugs, illegal or fake online pharmacies can cause side-effects or may give way to new health problems.

One of the most frequently question is what are the pros and cons of online pharmacies? Is it safe?

The internet pharmacy market is ever expanding and online medicine shopping is also increasing. There are quite a few patient safety risks connected to the online purchase of medicines outside the traditional supply chain, including counterfeit medications.

Dangers and the risks of buying medicines online:

 

  • Illegal or unethical online pharmacies with fake medicines:

    The internet is bombarded with fake pharmacies. The chances of purchasing from rogue websites or pharmacies are quite high. Also, many online pharmacies are unregistered, so purchasing from them is possibly unsafe as the medicines sold on the website might be diluted, out-of-date, or of sub-standard quality.

As per a research study, “the proportion of counterfeit medicine is predicted to be 10% worldwide varying from less than 1% in developed countries to over 30% in developing countries like Africa, India, and Latin America

  • Think before you self-medicate:

    If people diagnose their own condition and then get any prescription medication online without a prescription; the website supplying this medication is acting illicitly.Also, by practising self-medication, you can cause irrevocable damage to your health, particularly when it comes to potent drugs. Misuse or abuse of any drug can be habitual or have serious implications on human health, not just for the one person consuming it but for people at large.The solution for prescription-only medicines is that an online pharmacy must receive a legally valid prescription before providing the medication. This means you’ll either need a paper prescription or an electronic prescription from your GP or another healthcare professional.

Things to consider before going for online medicine shopping:

  • Check the official domain name: Pharmacies with the domain .pharmacy have been assessed by regulators.
  • Check the license: The genuine online pharmacy has their license displayed on the website. When you go through their website, it is there on their homepage. Keep an eye for it to test their authenticity!
  • Make sure they necessitate prescription: You should never be able to buy a prescription drug without a prescription.
  • Check their contact information: If they have nothing to hide, they will clearly mention their contact information.
    Check for the physical address for the online drugstore. If it doesn’t match the provided address or if the address doesn’t exist, you need to step back from buying medicines from there.
  • Do not be tempted by “spam” emails promoting medication at cheap prices. Be wary of these kinds of false promises.
  • Check for any complaints lodged against a specific online pharmacy. If you find any negative references or warning, you should avoid buying medicines from that pharmacy.

DCGI Approved Fixed-Dose Combinations for Diabetes Management

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DCGI Approved Fixed-Dose Combinations for Diabetes Management

Fixed-dose combinations (FDCs) are gaining popularity worldwide, considering their importance in disease management and better efficacy and safety profile.

It has always been a great topic of deliberation in the pharmaceutical industry, drug regulatory agency, pharmaceutical trade and public health point of view.

The increased therapeutic activity of FDC shows new possibilities in the treatment of almost every human disease. Fixed-dose combinations have been utilized in several disciplines of medicine, based on their convenience rate, and improved adherence rates.

What are Fixed-dose combinations (FDC)?

Fixed-dose combinations (FDC) can be defined as medications that contain two or more active ingredients combined in a fixed-dose in a single formulation. They exhibit similar bioequivalence, rates and therefore, similar pharmacokinetic and pharmacodynamic properties as separate tablets.

What are the advantages of using FDC Products over monotherapy?

1 . Better treatment

FDC’s can lead to better treatment outcomes by improving patient adherence rates. It also helps to     avoid treatment failure due to relapse.

2 . Improves patient compliance

FDC’s may improve patient compliance by taking fewer tablets daily. It significantly reduces pill burden of patients.

3 . Simple dosage schedule

FDC’s may reduce the confusion and complexity of dose schedule in treatment of some diseases such as tuberculosis that may require 5-16 tablets per day.

4 . Greater efficacy compared to monotherapy

FDC’s are more efficient than monotherapies, as per the data obtained from various research studies and clinical trials.

5. Reduced risk of adverse events

FDC’s have been reported to cause less adverse effects as compared to those of two drugs given independently.

6 . Synergistic effect

FDC’s creates a perfect combination that exhibits a synergistic effect. For instance, a fixed-dose combination of Paracetamol and Tramadol shows a synergistic effect with a quick onset of action and prolonged analgesic effect.

7 . Inhibition of microbial resistance

FDC’s are more effective in eliminating or slowing down antimicrobial resistance as compared to monotherapy as infectious pathogens at developing antimicrobial resistance against drugs.

Inhibition of microbial resistance

Regulation of FDC Products In India

Any new drug to be authorized and marketed in India is regulated by Drug Control General of India (DCGI), under the guidelines of Drugs and Cosmetic Act 1940. Before drug approval, Central Drugs Standard Control Organization (CDSCO) undergoes a clinical examination and monitors the drug formulations from the angle of quality, efficacy, safety and rationality.

1 . The marketing approval and rights to manufacture/import FDC’s are entirely based on the FDA guidelines. As per Rule 122 (E) of Drugs and Cosmetics Act 1940 and their Rules 1945, FDC’s are considered as a complete pharmaceutical product and a new drug.

2 . The approval of FDC’s is based on the appropriate therapeutic rationale of the particular combination of active substances. Confirmation can also be obtained from the scientific literature of scientific value.

3 . Comparative clinical trials of FDC’s with reference treatment may also be essential when the therapeutic explanation shows the superiority of FDC’s over a reference treatment.

4 . The application for marketing authorization should include original data, scientific literature and a combination of both. Chemical and pharmaceutical data should always be completely innovative unless there is enough explanation with literature when partial data can be in-original.

Fixed-Dose Combinations (FDC’s) and Diabetes

Diabetes mellitus is a chronic disease, with a growing prevalence worldwide.
According to the World Health Organisation (WHO), 422 million adults were suffering from diabetes globally in 2014. The estimated prevalence of diabetes in India was recorded to be 72 million cases in 2017. These figures are expected to double by 2025.

The first-line management of diabetes includes the use of biguanides, metformin. It is the most commonly used anti-diabetic drug. The potential of metformin as an effective drug is explained by its ability to lower blood glucose levels by decreasing glucose production, stimulating glucose uptake by muscles and increased fatty acid oxidation.

The exact mechanism of action is not fully understood yet. It is contraindicated or intolerable as the initial treatment in some patients. Therefore another class of anti-hyperglycemic agent are used.

Management of diabetes is also complicated because many barriers affect glycemic control. These barriers include risk of hypoglycemia, weight gain and complicated dosing schedules.

To reduce these barriers and achieve glycemic control targets, fixed-dose combinations of oral hyperglycaemic agents with metformin has been licensed for use in the management of diabetes mellitus.
The combination therapy using a second agent with a different mechanism of action is also favoured when monotherapy fails to achieve the glycemic goal.

There are six major classes of anti-diabetic agents that can be combined with metformin. They are sulfonylureas (SU), thiazolidinediones (TZDs), dipeptidyl peptidase-4 inhibitors (DPP4i), sodium-glucose cotransporter-2 inhibitors (SGLT2i), Alpha-glucosidase inhibitors (AGIs), and Meglitinide analogues.

Sulfonylureas

This class of medications includes a group of anti-hyperglycemic agents used as a combination therapy with metformin, a sulfonylurea or other anti-hyperglycemic agent. They are usually divided into first and second generations.
Examples of first-generation sulfonylureas include chlorpropamide, tolazamide, and tolbutamide, while second-generation sulfonylureas include glipizide, gliclazide, glyburide and glimepiride.

Sulfonylureas act by increasing the release of insulin through the stimulation of pancreatic beta cells. They have remained a frequently prescribed medication despite potential hypoglycemic risks.

CDSCO Approved fixed-dose combination of Sulfonylureas

1. Glipizide and Metformin: For non-insulin dependent diabetes mellitus

2. Glimepiride and Metformin: For the treatment of patients with type II diabetes mellitus, when diet, exercise and single-agent do not result in adequate glycemic control

3. Glimepiride, Pioglitazone and Metformin: Used as 3rd line treatment of type-II diabetes mellitus when diet, exercise and the single agents and second-line therapy with two drugs do not result in adequate glycemic control

4. Glimepiride, Metformin and Atorvastatin: For the treatment of type II diabetes mellitus associated with dyslipidemia

5. Gliclazide and Metformin: For the management of type-II diabetes, and non-insulin dependent diabetes (Type-II) in adult patients where single-drug therapy, diet and exercise do not result in adequate glycemic control

6. Gliclazide, Metformin and Rosiglitazone: For the management of all types of diabetes

7. Gliclazide, Metformin and Pioglitazone: Used as 3rd line treatment of type II diabetes mellitus when diet, exercise and the single agents and the second-line therapy with two drugs do not result in adequate glycemic control

8. Glibenclamide and Metformin: For the management of non-insulin dependent diabetes mellitus patients poorly controlled with sulphonylurea or biguanide alone and when single-drug therapy, diet and exercise do not result in adequate glycemic control

9. Glibenclamide, Pioglitazone and Metformin: Used as 3rd line treatment of type II diabetes mellitus when diet, exercise and the single agents and the second-line therapy with two drugs do not result in adequate glycemic control

Thiazolidinediones

Thiazolidinediones are a novel class of agents, which has been introduced to improve pancreatic β-cell function and insulin sensitivity. Two thiazolidinediones (rosiglitazone and pioglitazone) has been used in combinations for achieving glycemic control in patients with type II diabetes.
They act by regulating glucose and lipid metabolism in the body. They also exhibits anti-inflammatory, beneficial effects on cardiovascular risk factors, and also decreases blood pressure. The efficacy of these agents has been determined in clinical trials.

CDSCO Approved fixed-dose combination of Thiazolidinediones

1. Pioglitazone and Metformin: Used as second-line therapy in patients with type II diabetes mellitus when diet, exercise & the single agent do not result in adequate glycemic control

2. Pioglitazone and Glimepiride: For the treatment of type-II diabetes as 2nd line therapy when diet, exercise & initial therapy with glitazone or urea do not result in adequate glycemic control

3. Rosiglitazone and Metformin: For the treatment of patients with type-II diabetes when diet, exercise, and the single agent do not result in adequate glycemic control

4. Rosiglitazone and Glimepiride: For type II diabetes mellitus where diet, exercise and single-agent do not result in adequate glycemic control

Gliptins or Dipeptidyl peptidase-4 inhibitors (DPP-4s)
Gliptins are a new class of drugs that have revolutionized the treatment of type II diabetes. It includes alogliptin, anagliptin, sitagliptin, teneligliptin, vildagliptin, saxagliptin, and linagliptin.

These agents act by increasing insulin secretion, with an increase in blood sugar. They also suppress glucagon production in response to a carbohydrate-containing meal. They also decrease the risk of hyperglycemia and weight gain.
The efficacy of gliptins in monotherapy and combination with various type II diabetes medications has been demonstrated in multiple clinical trials.

CDSCO Approved fixed-dose combination of Gliptins

1. Vildagliptin and Metformin: For the treatment of type II diabetes mellitus when single-drug therapy along with diet, exercise do not result in adequate glycemic control

2. Sitagliptin and Metformin: Used as an adjunct to diet & exercise to improve glycemic control in patients with type- II diabetes mellitus. It is also indicated as an add-on to insulin(i.e. triple combination therapy) in patients when the stable dosage of insulin and metformin alone do not provide adequate control

3. Saxagliptin and Metformin: Used as an adjunct to diet and exercise to improve glycemic control in adults patients with type II diabetes mellitus when treatment with both Saxagliptin and Metformin is appropriate

4. Linagliptin and Metformin: Used as an adjunct to diet and exercise to improve glycemic control in adults with type II diabetes Mellitus when treatment with Linagliptin and Metformin is appropriate

5. Teneligliptin and Metformin: Used as an adjunct to diet and exercise to improve glycemic control in adults with type II diabetes mellitus when treatment with both teneligliptin and metformin is appropriate

Sodium-glucose cotransporter 2 (SGLT2) inhibitors

Sodium-glucose cotransporter 2 (SGLT2) inhibitors represent another class of anti-diabetic medication. It includes canagliflozin, dapagliflozin, empagliflozin, and ertugliflozin.

These drugs block glucose reabsorption by the kidneys resulting in increased urinary excretion of glucose. These drugs also promote weight loss, and remain hypoglycemic-neutral and also shoes cardiovascular benefit.

CDSCO Approved fixed-dose combination of SGLT2 inhibitors

1. Dapagliflozin and Metformin: Indicated as an adjunct to diet and exercise to improve glycaemic control in adults with type II diabetes mellitus when treatment with both Dapagliflozin and Metformin is appropriate.

2. Empagliflozin and Linagliptin: Used as an adjunct to diet and exercise to improve glycaemic control in adults with type II diabetes mellitus

3. Empagliflozin and Metformin: Used as an adjunct to diet and exercise to improve glycaemic control in adult patients with type II diabetes mellitus who are not adequately controlled on a regimen containing Empagliflozin or Metformin, or in patients already being treated with both Empagliflozin and Metformin.

4. Canagliflozin and Metformin: Indicated as an adjunct to diet and exercise to improve glycaemic control in the adult with type II diabetes mellitus when treatment with both Canagliflozin and metformin is appropriate. It is not used for the treatment of type 1 diabetes or diabetic ketoacidosis

5. Remogliflozin Etabonate and Metformin:

1 . Indicated in adults aged 18 years and older with type II diabetes mellitus as an adjunct to diet and exercise to improve glycemic control

2 . In patients insufficiently controlled on their maximally tolerated dose of metformin alone

3 . In patients already being treated with the combination of Remogliflozin and metformin as separate tablets

Alpha-glucosidase inhibitors (AGIs)

Alpha-glucosidase inhibitors (AGIs) are a class of anti-diabetic drugs derived from bacteria. It includes acarbose and voglibose. These oral drugs are enzyme inhibitors which work by delaying carbohydrate absorption in the gastrointestinal tract with improved cardiovascular benefit. They have been used in the early stages of type II diabetes to reduce postprandial hyperglycaemia.

CDSCO Approved fixed-dose combination of Alpha-glucosidase inhibitors (AGIs)

1. Acarbose and Metformin: For the treatment of patients with type II diabetes mellitus, when diet, exercise and single-agent do not result in adequate glycemic control

2. Voglibose and Metformin: Used as 2nd line treatment of type II diabetes mellitus when diet, exercise and the single agent do not result in adequate glycemic control

Meglitinide analogues

Meglitinide analogues are a class of oral hypoglycaemic agents that causes an increase in insulin secretion. It includes repaglinide and nateglinide. These agents increase insulin secretion by regulating ATP sensitive potassium channels in pancreatic beta cells.

CDSCO Approved fixed-dose combination of Meglitinide analogues

1. Repaglinide and Metformin: Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type II diabetes mellitus who are already treated with a meglitinide & metformin or who have inadequate glycemic control on a meglitinide alone or metformin

2. Nateglinide and Metformin: Used in patients with type-II diabetes in adequately controlled by diet, exercise and maximally tolerated dose of Metformin alone

By now, you must be aware of various fixed-dose combinations for treatment of diabetes mellitus licensed in India. These fixed-dose combinations are highly effective in controlling your blood sugar levels with a reduced rate of side effects and simple dosing schedules.

Hyperlipidemia: A Common Health Problem

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Hyperlipidemia is considered as one of the major risk factors causing cardiovascular diseases. According to World Health Organisation, approximately 2.6 million deaths (4.5% of total) and one-third of ischaemic heart disease are attributable to high cholesterol.

Hyperlipidemia is a lifelong condition which refers to abnormal levels of lipids (fats) circulating in the blood. These plasma lipids include triglycerides (neutral fats), cholesterol, and plasma lipoproteins (Fat-protein complex).

Cholesterol is a wax-like substance produced naturally in the liver to aid brain functioning, hormone production and cell function. It is transported to body cells using lipoproteins.

Lipoproteins are further categorised into Very Low-Density Lipoproteins (VLDL), Low-density lipoproteins (LDL), or bad cholesterol, and high-density lipoproteins (HDL), or good cholesterol. Both VLDL and LDL remains in the bloodstream, causing damaging effects on health whereas HDL is good for health as it takes excess cholesterol back to the liver for excretion.

Triglycerides are stored in fat cells to provide energy for cell function and metabolism.

Low levels of HDL and high levels of LDL with an elevated level of cholesterol and triglycerides cause plaque deposits, which grows longer over time. These deposits clog arteries and reduce the supply of oxygen to heart, ultimately leading to atherosclerosis, heart disease and stroke.

TYPES OF HYPERLIPIDEMIA

There are several types of hyperlipidemia depending on the different types of fats involved and how each type impacts the body.

The main types of hyperlipidemia are as follow:

Type I or hyperlipidemia familial lipoprotein lipase deficiency

It is the type of hyperlipidemia prevalent in childhood. It is an inherited condition which disrupts the breakdown of fats, thereby leading to infections in the pancreas, enlargement of the liver and abdominal pain.

Type IIa or familial hypercholesterolemia, and Type IIb, or familial combined hyperlipidemia

Both these types of hyperlipidemia result in high levels of LDL. It may cause fat deposits in the skin and around eyes. It can also lead to increased risk of heart problems.

Type III, or familial dysbetalipoproteinemia

It is the type of hyperlipidemia that affects the levels of lipoproteins. It usually occurs in when levels of LDL in blood are low. A typical feature of type III is the presence of yellowish-grey plaques on the eyelids and around the eyes. It also increases the early onset of cardiovascular disease.

Type IV, or hypertriglyceridemia

It is the type of hyperlipidemia that defines the increase in levels of triglycerides leading to obesity, high blood glucose, and high insulin levels. It is not caused until early adulthood.

CAUSES OF HYPERLIPIDEMIA

Being obese or overweight with a lack of physical activity and consumption of foods rich in saturated fats and cholesterol can contribute to hyperlipidemia. Beyond diet, some other secondary factors can also increase the risk of hyperlipidemia. It includes:

  • Family history of hyperlipidemia
  • Unhealthy lifestyle habits such as smoking and drinking
  • Certain health conditions such as diabetes, renal disease, and inherited conditions
  • Certain medications such as antidepressants, diuretics and birth control pills

SYMPTOMS OF HYPERLIPIDEMIA

Most of the people with hyperlipidemia does not have any apparent symptoms, but it is discovered by routine examination. It can cause chest pain along with swelling in the liver and nodules formed on the knees.

DIAGNOSIS OF HYPERLIPIDEMIA

The diagnosis of hyperlipidemia can be made by evaluation of LDL, HDL, VLDL and triglycerides levels in the blood test. A person may have hyperlipidemia if they have one or a combination of following:

  • Higher LDL and VLDL levels
  • Lower HDL levels
  • Higher total cholesterol levels
  • Higher triglyceride levelsHYPERLIPIDEMIA: A COMMON HEALTH PROBLEM

The following table highlights the optimal levels of triglycerides, lipoprotein and cholesterol:

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PREVENTION: LIFESTYLE MODIFICATIONS TO MANAGE HYPERLIPIDEMIA

Being physically active with an improvement in diet and reduction in excess weight are the best ways to prevent and manage hyperlipidemia. Various lifestyle measures can help to prevent high cholesterol or reduce your risk of developing hyperlipidemia:

Exercise regularly

Regular exercise and physical activity help to encourage weight loss and reduce bad cholesterol levels. A total of 150 minutes of moderately intense exercise per week is recommended in patients with hyperlipidemia.

Avoid foods with saturated and trans fat

Fried foods and foods such as red meat, bacon, sausage, and full-fat dairy products should be avoided. People should switch to lean proteins like chicken, turkey, fish and low-fat or fat-free dairy. Monounsaturated fats like olive and canola oil should be used for cooking.

Eat a heart-healthy diet

A heart-healthy diet includes a variety of whole fruits, vegetables, high-quality proteins, plenty of fiber, lots of water, and whole-grain foods. This diet not only decreases cholesterol levels but also reduces the risk of cardiovascular disorders.

Maintain a healthy weight

Overweight and obesity raise levels of bad cholesterol. Losing weight can help to reduce cholesterol levels. To lose weight, adopt a low-calorie diet and increase physical activity to burn extra calories.

TREATMENT: DRUGS USED TO MANAGE HYPERLIPIDEMIA

Along with lifestyle measures, specific cholesterol and triglyceride-lowering medication are also prescribed. Currently, antihyperlipidemic drugs contain five significant classes that include statins, fibric acid derivatives, bile acid-binding resins, nicotinic acid derivatives and drugs that inhibit cholesterol absorption. Monotherapy is effective in managing hyperlipidemia, but combination therapy may also be required for a comprehensive approach.

These drug classes are explained as below:

3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA)reductase inhibitors (statins):

Statins are prescribed for lowering higher cholesterol levels. It includes drugs such as:

  • Lovastatin
  • Simvastatin
  • Pravastatin
  • Fluvastatin
  • Atorvastatin
  • Rosuvastatin

Other HMG-CoA reductase inhibitors include the diallyl disulfide (DADS) and diallylthiosulfinate. These drugs are described as structural analogues of HMG-coenzyme A reductase.

Mechanism of action:

They inhibit rate-limiting enzyme (HMG-coenzyme A reductase) in the biosynthesis of cholesterol in the liver. Inhibition of the enzyme results in reduced plasma levels of total cholesterol (TC), LDL and ApoB. Statins also cause a decrease in plasma triglycerides levels and a small increase in plasma level of HDL.

Efficacy and Safety:

Research studies indicate that statins can achieve 20%–50% reductions in cholesterol levels with a reduced incidence of coronary morbidity and mortality in high-risk adults. Statins are frequently well-tolerated but can cause some common adverse effects such as gastrointestinal symptoms, headache, and dizziness. These symptoms are more common with higher doses and may reduce if dose and another statin can be used.

Bile acid sequestrants

Bile acid synthesis is the primary pathway of cholesterol catabolism in the liver. It is estimated that about 500mg of cholesterol is converted into bile acid in the liver. Bile acid plays an integral role in the absorption of fats from foods. Bile acid sequestrants include:

  • Cholestyramine
  • Colestipol
  • Colestimide
  • Colesevelam

Mechanism of action

Bile acid sequestrants are positively charged resins. They act by binding to the negatively charged
bile acids in the intestine to form a large insoluble complex. This complex is not absorbed and therefore excreted in the faeces. It also increases the excretion up to tenfold, resulting in greater conversion of cholesterol to bile acids. Furthermore, bile acid sequestrants increase HDL levels.

Efficacy and Safety

Bile acid sequestrants are rarely used as initial therapy due to poor patient tolerance. The most common adverse effects experienced are constipation, nausea, indigestion, bloating and flatulence.

Fibric acid derivatives (Fibrates)

Fibrates are a widely used class of antihyperlipidemic agents. It includes :

  • Clofibrate
  • Gemfibrozil
  • Fenofibrate
  • Bezafibrate

Mechanism of action

Fibrates exhibit multiple mechanisms of action. It acts by stimulating lipid degradation, increases hepatic fatty acid (FA) uptake and increases the removal of LDL particles and HDL production.

Efficacy and safety

Clinical trials indicated that fibrates result in a significant reduction in plasma triglycerides and a modest reduction in LDL cholesterol. It also increases the levels of HDL cholesterol level. Fibrates also decrease the progression of coronary atherosclerosis and reduce the incidence of coronary artery disease. Generally, fibrates are well-tolerated but can lead to some side effects such as gastrointestinal symptoms, skin rashes and gallstones. The use of fibrates should be avoided in patients with liver and renal dysfunction.

Nicotinic acid derivatives (Niacin)

Niacin, a type B vitamin is the oldest lipid-lowering agent used to treat hyperlipidemia proved to decrease cardiovascular morbidity and total mortality.

Mechanism of action

Niacin acts by blocking hormone-sensitive lipase, which decreases triglycerides lipid degradation. It also inhibits VLDL secretion, in turn, reduce the production of LDL. It also elevates HDL cholesterol concentrations by increasing HDL synthesis.

Efficacy and safety

Niacin effectively decreases total cholesterol, LDL cholesterol, triglycerides. Niacin treatment can lead to common side effects such as nausea, abdominal discomfort, itching and headache.

Selective cholesterol absorption inhibitor (Ezetimibe)

Ezetimibe is the first member of a group of drugs which has improved the treatment of elevated cholesterol levels.

Mechanism of action

Ezetimibe acts by selectively inhibiting the absorption of cholesterol in the small intestine, leading to a decrease in the intestinal cholesterol to the liver. It also causes an increase in the clearance of
cholesterol from the blood.

Efficacy and Safety

Research studies have indicated the effectiveness of ezetimibe in the treatment of elevated cholesterol levels. A combination of ezetimibe and statins can achieve a reduction in LDL cholesterol levels
by 25%, compared to 6% attained by doubling the statin dose. Ezetimibe is usually well tolerated but can cause headache, abdominal pain and diarrhoea in patients.

Other New potential targets and treatments:

Recent clinical trials have discovered new potential agents with promising antihyperlipidemic
activity. These drug classes act by inhibiting necessary steps in pathways involved in the formation and breakdown of cholesterol. Some of these treatments are as follow

  • Acyl-CoA cholesterol acyltransferase inhibitors (ACAT) including Avasimibe and Eflucimibe
  • Microsomal triglyceride transfer protein (MTP) inhibitors including Oflomitapide
  • Cholesteryl ester transfer protein (CETP) inhibitors including Dalcetrapib and Anacetrapib
  • Squalene synthase inhibitors including BMS-188,494 and YM-53601
  • Hydroxymethylglutaryl-CoA synthase inhibitors including L-659,699
  • ATP citrate lyase inhibitors including BMS-303141
  • Acyl coenzyme A: diacylglycerol acyltransferase (DGAT) including T863
  • Squalene epoxidase inhibitors including NB-598
  • Lanosterol synthase inhibitors including U18666A and Ro 48-8071

CONCLUSION
Hyperlipidemia is an asymptomatic problem but often treatable. It should be cured as it is associated with harmful diseases like atherosclerosis, cardiovascular disorders, high blood pressure and other severe problems which seriously affect the human body. Early diagnosis and preventive measures can easily reduce the risk of developing hyperlipidemia.

How to Take Care of Hair Naturally? It’s Easy if you do it smart

by new_pharma new_pharma No Comments

This is the biggest question of all age groups nowadays that how to take care of hair naturally? Yes! It’s true that people get a variety of advice when it is about taking care of and styling hair.

But still accepting the best advice and getting the desired results is like a game of gamble because you never know that what that remedy is going to do with your hair. Sometimes you get what you expected, but sometimes it just affects your hair severely, so the best way to treat your hair is adopting the natural methods for taking care of hair. Here are some great and easy ways to take care of hair naturally:

Oil is Your Best Friend

Oiling the scalp and hair regularly do wonder to your hair:

  • It conditions your hair
  • It promotes the fastest hair growth by increasing the circulation of the hair follicle.
  • It gives beautiful texture and shines to your hair.

Deep Conditioning But in a Right Way

Deep hair conditioner after every hair wash is your best habit to keep your hair healthy. But you should know the right way to condition your hair. Conditioner should not be applied to the scalp because it is not useful or your scalp and can make your hair excessively oily.

The right way to condition your hair:

  • Always apply the conditioner 2 inches away from your scalp till your hair ends.
  • Keep as it is for about 5 – 10 minutes.
  • Then rinse it off with cold water.

First Dry Then Comb Hair

Damp hairs are very tender and weak, so comb those leads to comparatively more hair loss. So the best way to avoid this condition is to dry your hair first by a soft tap with the towel then leave them to dry for some time after that comb them gently.

Trim Your Hair – Bye-Bye Split ends

Split ends are not suitable for your hair health as they are the damaged hair and also damages the further hair leads to more hair breakage and flyaway. So trimming your hair of about 1/4th an inch after every 6 – 8 weeks makes your hair thicker, shiny and overall healthy.

Egg Treatment for Happy Hair

The egg is the most significant source of the protein and hair are majorly made up of proteins, so providing egg benefits to the hair directly make them happier and healthier than before. Way to have egg treatment:

  • Prepare the mixture of whole 1 or 2 egg according to the hair length and volume.
  • Apply this mixture to your clean and damp hair.
  • Leave this for 20 minutes and then rinse it off with cold water.

Use Gentle Shampoo for Soft Hair

The various shampoo contains sulphate and paraben in it, which is not suitable for the health of the hair. Hair growth shampoo should not contain sulphates and paraben which cause irritation and eye problems when applying for a long time. So a better way to avoid this problem is to use natural cleansers instead of these chemicals.

Say Bye to Hot Water

Hot water is responsible for making your hair and scalp dry, which leads to the brittle and frizzy hair that breaks easily. In place of this cold water conditions the hair and makes them lustrous and shiny by closing the pores and cuticles in the scalp. So say bye-bye forever to hot water for hair washing.

Avoid Heat Styling – Stay Natural

Heat styling the hair is not the hair loss condition, but it is the way to make your hair weaker day by day because of heat styling, blow drying, straightening hair and using the styling products damages hair, make them thinner than the natural hair which tends to break easily results in significant hair loss. So staying natural and avoiding all these things can make your hair healthy.

Colouring Makes Your Hair Upset

Hair colouring dyes and products contain a high amount of ammonia and peroxide in it, which damages the subsequent hair loss. Hair dyes also remove the melanin (hair colour pigment) from the hair which also responsible for the weakening of the hair results to hair loss. If you are currently dealing with the same kind of hair loss then hair growth serum will work best for you otherwise staying with your natural hair colour is the better way to take care of hair naturally.

Hair Protection is Better Option

The environment also plays a significant role in affecting the health of the hair. Exposure of hair to sun, dirt, pollution and many more can lead to the dryness of the hair and scalp and the build-up of dust that can increase susceptibility to infections on the scalp. So protection is the better option which can be done by covering the hair by using an umbrella, hat and scarf while you are in exposure to these harmful aspects.

These are the ways to take care of the hair naturally. Try these ways in your life and see the visible healthy change to your hair!